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Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery

RecruitingNAAges 18 Years - 70 YearsAllCliniques universitaires Saint-Luc- Université Ca…
NCT06776042 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks. * Endoscopic visualisation of bilateral sinonasal polyps * SSI (TDI) \< 30.75 and decreased sense of smell subjectively * Eosinophilia \> 300/μl of blood Ku/l * On a stable nasal steroid treatment for at least 4 weeks Exclusion Criteria: * Active smoking * Primary and secondary immune deficiencies * Ciliary diseases (cystic fibrosis, primary ciliary diskinesia) * History of or current nasal malignancies * \< 18 years and \> 70 years * Patients unable to express consent * Use of systemic corticosteroids for \< 4 weeks before visit 1 • Use of systemic or local antibiotics for \< 4 weeks before visit 1
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What it tests

  • Nasal brushing of the olfactory cleft
  • Smell testing
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Where

1 site
Cliniques Universitaires Saint-Luc
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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