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Physical Activity and Insulin Sensitivity Dynamics

RecruitingNAAges 22 Years - 35 YearsMaleUniversity of Copenhagen
NCT06776094 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. This will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy individuals (no known diseases) * No use of medication * Non-smokers * Male * Aged 22-35 years * Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg * BMI between 28 and 35 Exclusion Criteria: * Women * Failure to meet all inclusion criteria * Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week * Acute illness within 2 weeks prior to the study days * Use of recreational drugs within 2 weeks prior to the study days
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What it tests

  • One-legged-knee extensor exercise
  • Insulin infusion
  • Muscle Biopsy Medication: Lidocaine
  • Exercise
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Where

1 site
University of Copenhagen, August Krogh Section for Human and Molecular Physiology
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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