Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation

Inclusion: * Age ≥18 years * Weaning from mechanical ventilation with tracheostomy Exclusion Criteria: * Longstanding tracheostomy, defined as tracheostomy being present prior to current hospital admission * Tracheostomy primarily indicated for chronic upper airway obstruction or to secure airway patency due to persistent stupor/coma * Chronic positive pressure respiratory support at home (excluding night-time continuous positive airway pressure for sleep apnea) * Mucociliary disease in medical history (e.g. cystic fibrosis, pulmonary ciliary dyskinesia) * Neuromuscular disease in medical history (excluding ICU-acquired weakness) * Contra-indication placement oesophageal balloon for measurement of PES, such as: * Fractures in mandibular, orbital or ethmoid bone or skull base * Esophageal varices or surgery in medical history * Severe bleeding disorders * Hemoptysis in 72 hours prior to the first disconnection session. Clinically relevant hemoptysis is defined as hemoptysis requiring tracheal/endobronchial or radiologic intervention, or administration of pro-coagulating drugs such as tranexamic acid.