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COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children

Recruitingn/aAges 8 Years - 18 YearsAllAmerican University of Beirut Medical Center
NCT06777875 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries. The main question\[s\] it aims to answer \[is\]: Do OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries? Participants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All children 8 years to 18 years * Undergoing orthopedic, abdominal, thoracic, and plastic surgeries * American Society of Anesthesiologists classification (ASA) I-II-III Exclusion Criteria: * Children with schizoid personality disorders, phobias, and anxiety * Patients with neuropathic pain associated with surgeries requiring surgical treatment. * Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse. * American Society of Anesthesiologists classification (ASA) ≥IV * All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.
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What it tests

  • Not listed
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Where

1 site
Roland Kaddoum
Beirut, Lebanon
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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