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Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline

Recruitingn/aAges 5 Years - 39 YearsAllTata Memorial Centre
NCT06779487 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Radiation constitutes an integral component in the management of primary brain tumors in pediatric and young adults like medulloblastoma, ependymoma, low-grade glioma, pituitary tumors, etc. A decline in neurocognitive outcomes is a multifactorial effect occurring from the primary disease as well as associated with treatments, including radiation. Since many of these tumors are highly curable, it is crucial to reduce long-term side effects, including memory loss, to improve the quality of life in these patients, leading to better rehabilitation. Radiation-induced neurocognitive deterioration is postulated to occur from multiple factors like neuroinflammation, vascular damage, and depletion of neural stem cells. The proposed study will prospectively evaluate 200 pediatric and young adults with brain tumors treated with radiotherapy. Biological samples (peripheral blood and cerebrospinal f

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 5-39 years 2. Histological diagnosis of primary brain tumor 3. Decision for treatment with radical intent radiotherapy 4. Signed assent and parental consent form for pediatric age group and signed consent form for adults. Exclusion Criteria: 1. Inability to undergo neurocognitive evaluation 2. Palliative radiotherapy. 3. Expected life expectancy \< 1 year
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What it tests

  • Not listed
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Where

1 site
Tata Memorial Hospital (TMH) Parel, and Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar
Mumbai, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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