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Structural Characteristics of Trunk and Limb Muscles in Cachectic Colorectal Cancer Patients

Recruitingn/aAges 18 Years - anyAllHasselt University
NCT06780423 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Until now, cancer is still associated with high morbidity and mortality, and is therefore a big issue for the public health. Colorectal cancer is the second leading cause of cancer death in developed countries. In advanced colorectal cancer, 60% of these patients develop cachexia. The presence of cachexia plays an important role in the high mortality rate of cancer. Cachexia is characterized by involuntary weight loss with loss of skeletal muscle with or without loss of fat mass. The aim of this study is to determine the feasibility of taking muscle biopsies of cachectic colorectal cancer patients. Skeletal muscle characteristics will be compared between biopsies of the m. erector spinae and the m. vastus lateralis from cachectic colorectal cancer patients, non-cachectic colorectal cancer patients and healthy controls. 10 cachectic, 25 non-cachectic, and 25 healthy controls will be rec

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📋 Eligibility rules (as published)
Cachectic colorectal cancer patients. Inclusion criteria: * minimum age of 18 years old * unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia * Cachexia staging score (CSS): 5-12 Exclusion Criteria: * Mental of psychological condition * Insufficient knowledge of the Dutch language * Muscle diseases affecting the spine and lower limbs * Bedridden Non-Cachectic cancer patients. Inclusion criteria: * minimum age of 18 years old * No unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia * Cachexia staging score (CSS): 0-2 Exclusion criteria: * Mental of psychological condition * Insufficient knowledge of the Dutch language * Muscle diseases affecting the spine and lower limbs * Bedridden Healthy controls. Inclusion criteria: \- minimum age of 18 years old Exclusion criteria: * Mental of psychological condition * Insufficient knowledge of the Dutch language * Muscle diseases affecting the spine and lower limbs * Bedridden
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What it tests

  • Minimal invasive fine needle muscle biopsies
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Where

2 sites
Hasselt University - REVAL research institution
Diepenbeek, Belgium
Jessa Hospital
Hasselt, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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