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Evaluation of Urinary Biomarkers Trend in Preterm Very Low Birth Weight Infants

Recruitingn/aAges any - anyAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT06781476 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to define the temporal patterns of urinary biomarkers (CysC, EGF, KIM-1, NGAL, ฮฒ2-Microglobulin, OPN, and MOD) in the first two weeks of life in preterm and/or very low birth weight (VLBW) infants in relation to the effect of specific factors (hsPDA, prenatal Doppler alterations) and drug therapies. Another objective is then to evaluate the predictivity of these biomarkers with respect to the occurrence of renal damage in preterm infants and possible cut-off values

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Gestational age \<32 weeks or birth weight \<1500 g; * Admission at birth to the Neonatal Intensive Care Unit of the IRCCS A.O.U. of Bologna Policlinico di S. Orsola; * Obtaining informed consent from parents/legal representatives. Exclusion Criteria: * malformations of the urinary system; * major congenital anomalies, including congenital heart disease; * syndromic picture or known genetic abnormalities; * perinatal asphyxia (defined by the finding on arterial blood gas from cord blood of pHโ‰ค7.0 or base excess โ‰ค-12 mMol/L and/or Apgar โ‰ค5 or need for resuscitation at 10' of life); * infants who died in the first 48 hours of life or underwent major surgery during the study period.
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What it tests

  • Not listed
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Where

1 site
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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