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Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation

RecruitingNAAges 18 Years - anyAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT06782880 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The increasing emergence and spread of MDRB represents a major public health problem, with higher mortality in patients experiencing infections. Cirrhotic patients listed for OLT and after OLT are at high risk of MDRB colonization or infection due to the large use of broad-spectrum antibiotics in the post-transplant setting. Therefore, effective decolonization strategies in this particular setting are urgently needed. The investigators hypothesize that heterologous FMT can reduce infections rates in the pre-and post- OLT setting by MDRB decolonization and restoration of a more physiological microbiome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult (age≥18 years) patients listed for OLT for various etiologies. * Patient's consent to participate in the study Exclusion Criteria: * Previous total colectomy * Pregnancy or breastfeeding * Patients on oral or intravenous antimicrobial agents * HIV positive and not well controlled on antiretroviral therapy, or CD4+ \<200/ mm3 * Active SARS-CoV-2 infection * Neutropenia \<0.5X10\^9/L * Toxic megacolon * Contraindications to colonoscopy * Any conditions for which, according to the physician, FMT endangers the patient's health * History of hypersensitivity to macrogol contained in bowel preparations.
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What it tests

  • Fecal microbiota transplantation (FMT)
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Where

1 site
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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