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The Role of Ectopic Fat and Heart Attack Risk in HIV

Recruitingn/aAges 40 Years - anyAllUniversity of Liverpool
NCT06784154 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is designed to investigate differences between people living with HIV (PLWHIV) and general populations on how the body utilises and stores energy. This study uses magnetic resonance imaging (MRI) to measure fat around the body organs including the heart and liver. The fat around body organs, also known as visceral fat, is known to be associated with metabolic syndrome and a risk factor for developing heart attacks and strokes. MRI scans are used frequently in hospitals to diagnose a range of conditions. These scans use radio waves to measure protons in body tissues. The machines can reconstruct tissues using complex algorithms to form composite images of body structures. MRI scans do not use ionising radiation and there is no risk to undertaking an MRI in terms of radiation. We often use MRI scans to assess the hearts' structure and function. In addition, we can use specific

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📋 Eligibility rules (as published)
Inclusion Criteria: * • \>40 years * HIV-positive * Stable ART for \>6 months with two VL \<40 copies/ml based on local testing protocols * CD4 count \>200cells/mm3 for \>2 years from recruitment Inclusion Criteria (all) * Understand the study procedures, able to comply with study procedures and voluntarily agree to participate by giving informed written consent Exclusion Criteria: * Subjects unable to comply with the study protocol * History of severe renal impairment (eGFR \<30ml/min) * History of severe hepatic impairment (Child Pugh Score \>9) * Active hepatitis B or hepatitis C * Any active illness, which in the opinion of the investigator precludes participation in the study. * History of cancer * Active illicit intravenous drug use * Investigators may decide the subject cannot proceed if there are any relevant other abnormal results in screening assessments * History or current GLP-1 agonist use * For female subjects: pregnancy or breast feeding at screening. * Subjects currently taking: Atypical antipsychotics, omega 3 supplements, Telmisartan/Irbesartan, Thiazolidinediones or regular NSAID use. * Familial hypercholesterolaemia
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What it tests

  • Non-interventional
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Where

1 site
Royal Liverpool University Hospital
Liverpool, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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