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Proprioceptive, Fear-related and Inflammatory Factors in the Persistence of Pregnancy-related Lumbopelvic Pain.

RecruitingNAAges 18 Years - 40 YearsFemaleHasselt University
NCT06785909 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pregnancy-related lumbopelvic pain (PLPP) affects 50-90% of pregnant women and is often dismissed as a normal part of pregnancy. However, the long-term consequences can be dramatic. Up to 21% of women with PLPP still have pain three years postpartum, and 10% experience disability, poorer quality of life, and lower ability to work 11 years after delivery. Because the multifactorial etiology of PLPP is unclear, prevention and treatment fall short. Previous studies on the causes of PLPP focused on impairments in motor output but ignored that impairments in sensory input (e.g., proprioception, the primary expertise of our research group) often precede motor output problems. Moreover, though psychological factors such as fear (of movement) are known to affect PLPP, their predictive role in PLPP remains understudied. Finally, the role of systemic inflammation in PLPP has yet to be examined, de

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📋 Eligibility rules (as published)
Inclusion Criteria: * Informed consent to participate * 18-40 years old * Pregnant * Singleton pregnancy (confirmed through ultrasound) * No current PLPP * Dutch- or English-speaking Exclusion Criteria: * Pregnant for more than 16 weeks * Currently experiencing PLPP, or having had PLPP during the index pregnancy * History of surgery or major trauma to the spine or pelvis, major trauma or surgery to the lower limbs more than 2 years ago with current residual symptoms (e.g., pain, instability, stiffness), major trauma or surgery to the lower limbs less than 2 years ago * Specific vestibular or balance disorders * Use of medication that could affect balance (e.g., ototoxic or centrally-acting drugs) * Having a medical diagnosis for, being treated by a rheumatologist for, or taking medication for a rheumatic condition * (History of) a neurological disorder (e.g., neuropathy) * Problems with vision that are not corrected by glasses, contact lenses or surgical eye correction * Recent history of ankle problem (e.g., ankle sprain less than 3 weeks ago) * Being on absolute/relative bed rest due to pregnancy complications * (History of) inflammatory (e.g., gout, endometriosis), (auto)immune (e.g., lupus, ankylosis spondylitis, rheumatoid arthritis, psoriasis, Crohn's disease, Graves' disease, Hashimoto's thyroiditis, colitis ulcerosa, multiple sclerosis, etc.), hypothyroidism, or cancer. * Having (had) a formal diagnosis of a psychiatric disorder (e.g., psychotic disorder).
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What it tests

  • Assessment of postural control, body perception, psychosocial factors and inflammation
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Where

2 sites
Hasselt University
Hasselt, Belgium
KU Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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