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Exploring Minor Proteins and Peptides in Human Milk: a Proteomic Analysis Across Lactation Stages

Recruitingn/aAges 0 Days - 120 DaysAllMaimónides Biomedical Research Institute of Córdo…
NCT06787963 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Human milk (HM) is the optimal food source for the nutrition, growth, and development of newborns. The protein fraction of HM plays a crucial role in the healthy development of infants. HM contains a wide variety of minor whey proteins and peptides with important bioactive functions, many of which are still unknown. Proteomics allows for the study of biological samples with inherently complex protein mixtures. Proteins are essential for the development of living organisms, both in quantitative and qualitative terms. The combination of proteomic techniques currently enables the study of protein variability and minor peptides in HM across different lactation stages and allows for differential quantification according to gestational age and birth weight. However, studies on the human milk serum proteome during these stages are limited. The aim is to explore the minor whey proteins and pepti

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy mothers * With monitored pregnancies within the care area of the Reina Sofía University Hospital in Córdoba * With newborns expected to be exclusively breastfed until 4 months Exclusion Criteria: * Mothers whose newborns have any of the following conditions: congenital malformation, chromosomal abnormality, hypoxia-ischemia, gastroschisis, polycythemia, hypoglycemia, sepsis, blood incompatibility * Pathological pregnancy, pregnancy by in vitro fertilization, or multiple pregnancies * With no plan to exclusively breastfeed until 4 months * Under medical treatment * Have a drug addiction * Refuse informed consent * Have had previous breast surgery * Live outside the metropolitan area
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What it tests

  • Not listed
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Where

2 sites
Hospital Universitario Reina Sofía
Córdoba, Spain
Maimonides Biomedical Research Institute of Cordoba (IMIBIC)
Córdoba, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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