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Reducing Overuse of Antibiotics With Decision Support

RecruitingNAAges 6 Months - 17 YearsAllVanderbilt University Medical Center
NCT06788093 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research. LRTIs (pneumonia, bronchiolitis, and infection-related exacerbations of asthma) account for nearly one-third of all emergency department (ED) visits and 40% of all infection-related hospitalizations in US children. LRTIs also account for more antibiotic use in children's hospitals than any other condition, despite most LRTIs being viral in nature. Inappropriate antibiotics are associated with substantial adverse effects. Accordingly, national guidelines strongly discourage routine antibiotic use for bronchiolitis and acute asthma and argue for significantly reducing antibiotic exposure (initiation, spectrum, and duration) in pneumonia. To address the problem of inappropriate antibiotic use, hospital-based antimicrobial stewardship programs (ASPs) are now

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. ED encounter or admission to an inpatient hospital team. 2. EHR-based positive screen for suspected LRTI, defined as a qualifying chief complaint (e.g., cough, shortness of breath, etc.), plus triage documentation of abnormal respiratory effort and/or cough. Exclusion Criteria: None
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What it tests

  • ED Clinical Decision Support (CDS-ED)
  • Transitions Clinical Decision Support (CDS-Tr)
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Where

3 sites
Benioff Children's Hospital - Oakland
Oakland, United States
Benioff Children's Hospital - San Francisco
San Francisco, United States
Monroe Carell Jr Children's Hospital at Vanderbilt
Nashville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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