Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls

Inclusion criteria patients: 1\. Adult patients with confirmed diagnosis of Arginine Vasopressin deficiency (central diabetes insipidus)2 or with only anterior pituitary deficiency Inclusion criteria healthy controls: 1. Adult healthy controls 2. Matched for age, sex, Body mass index, and oestrogen replacement/menopause/hormonal contraceptives to patients 3. No medication, except hormonal contraception Exclusion Criteria: 1. Participation in a trial with investigational drugs within 30 days 2. Illicit substance use (except for cannabis) more than 10 times in lifetime or any time within the previous two months 3. Consumption of alcoholic beverages \>15 drinks/week 4. Tobacco smoking \>10 cigarettes/day 5. Cardiovascular disease (coronary artery disease, heart failure Left ventricular ejection fraction \<40%, stroke in the last 3 months, atrial fibrillation/flatter, Wolff-Parkinson-White-Syndrome) 6. Uncontrolled arterial hypertension (\>140/90 mmHg) or hypotension (\<85mmHg) 7. Current or previous major psychiatric disorder (e.g., major depression, schizophrenia spectrum disorder) 8. Psychotic disorder in first-degree relatives 9. Regular intake of selective serotonin reuptake inhibitors or Monoamine oxidase inhibitors 10. Pregnancy and breastfeeding 11. Diagnosed Chronic Kidney Disease \> grade III (glomerular filtration rate \< 30ml/min) 12. Diagnosed liver cirrhosis or alanine aminotransferase (ALAT) or aspartate aminotransferase (ASAT) levels 2.5 times above the normal range