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Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder

RecruitingPhase 1Ages 18 Years - anyAllUniversity of Minnesota
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In plain words

What the trial is, and whether it could suit you

The study will recruit 50 adults with stimulant use disorder currently in treatment and abstinent for at least 2 weeks. The study will also recruit up to 10 healthy controls (adults without StUD) for initial study configuration. The study will consist of five steps that are expected to be completed over two lab visits. Step 1: The 3T MRI scan will provide accurate prefrontal cortex anatomy for using neuronavigation for TMS. In addition, the study will use an analysis of resting fMRI connectivity to determine the location in the left DLPFC that has the maximum connectivity with the incentive-salience network. Step 2: The study will use the data collected at the MRI to select the individual TMS location. EEG will be used to collect TEPs in response to single pulse TMS at the left DLPFC. Participants will then be randomized to one of three conditions: A) TMS unsynchronized with EEG, B) TM

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18 or older * Ability to provide consent and comply with all study procedures. * Meets Diagnostic and Statistical Manual of Mental Disorders criteria for StUD (As assessed by MINI and self-report; Participants may have current comorbid drug use, but primary diagnosis must be StUD; does not apply to healthy control participants). * At least 2 weeks of abstinence from substance use (other than caffeine or nicotine). * Intention to remain in an addiction treatment program until intervention completion (does not apply to healthy control participants). * Confident level of English language proficiency. Exclusion Criteria: * Any organic brain disorder (e.g. TBI, stroke). * Head injury resulting in skull fracture or loss of consciousness exceeding 30 minutes. * TMS contraindication (history of seizures, metallic cranial plates/screws or implanted device). * MRI contraindications (unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, claustrophobia). * Any psychotic disorder (Participants with other treated and stable psychiatric disorders will be included). * Presence of a condition that would render study measures impossible to administer or interpret. * Primary current substance use disorder diagnosis on a substance other than stimulants or cocaine, except for caffeine or nicotine. * Greater than 9 months abstinence from substance use (does not apply to healthy control participants). * Pregnancy or breastfeeding.
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What it tests

  • closed-loop-peak
  • Open-loop
  • closed-loop-trough
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Where

1 site
University of Minnesota
Minneapolis, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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