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Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial

RecruitingPhase 4Ages 18 Years - anyAllMount Sinai Hospital, Canada
NCT06792214 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults. Additionally, this pilot study will inform the design and conduct of a future full-scale multi-centre trial by testing the feasibility and accuracy of this study design.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥18 years old * Positive PCR test for SARS-CoV-2 within 5 days of admission to hospital * Normoxic (not receiving supplemental oxygen) * Able to provide informed written consent (or, if patient is unable, have substitute decision maker available) Exclusion Criteria: * Absolute contraindications to Paxlovid or Veklury (any of the following): Severe allergy to Paxlovid or Veklury (e.g. anaphylaxis), co-administration with drugs highly dependent on CYP3A for clearance, co-administration with potent CYP3A inducers * Exposure to Paxlovid or Veklury within previous 14 days; * Receiving supplemental oxygen; * Known positive SARS-CoV-2 PCR or rapid antigen test 5-90 days prior to admission; * Limited life expectancy estimated to be ≤3 months; * Pregnant and breastfeeding women
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What it tests

  • Nirmatrelvir/ritonavir
  • Remdesivir
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Where

4 sites
Kingston Health Sciences Centre
Kingston, Canada
Niagara Health System
St. Catharines, Canada
Mount Sinai Hospital, Sinai Health System
Toronto, Canada
St. Joseph's Health Centre, Unity Health Toronto
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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