RWE Non-Interventional Prospective Study of Ribociclib Effectiveness and Safety in Patients With HR+/HER2- Early Breast Cancer in Saudi Arabia

Inclusion Criteria: 1. Signed and dated Patient Informed Consent Form (PICF) obtained. 2. The patient is ≥ 18 years-old at the time of PICF signature. 3. Male or female patients with estrogen-receptor-positive and/or progesterone-receptor-positive BC. 4. Male or female patients with HER2- BC. 5. Patients who are currently receiving ribociclib in combination with adjuvant ET as per approved local label for up to 6 months prior the enrollment date. 6. Male or female patients with American Joint Committee on Cancer (AJCC) Anatomic Stage Group IIA(subset) /IIB or Anatomic Stage Group III EBC. 7. Female patients with known menopausal status (at the time of PICF signature or initiation of adjuvant ET, whichever occurs earlier), or male. Exclusion Criteria: 1. Ribociclib-based treatment regimen beyond adjuvant therapy for EBC. 2. Patients are currently participating in any other clinical trials. 3. Patients who previously received any other CDK4/6 inhibitor. 4. Patients who refused to sign informed consent. 5. According to the investigator's opinion, the patient is an unlikely candidate to provide an accurate medical history and/or to obtain long-term follow-up information for any reason.