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Role of Menopause in Thermoregulation

RecruitingPhase 4Ages 42 Years - 64 YearsFemalePenn State University
NCT06798571 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women ages 42-64 Exclusion Criteria: * Chron's disease, diverticulitis, or similar gastrointestinal disease * Abnormal resting exercise electrocardiogram (ECG) * Tobacco use * High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor * Assessment * Using hormone therapy * Using hormonal contraceptives
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What it tests

  • Elagolix Oral Tablet
  • Estradiol patch
  • cellulose placebo
  • placebo patch
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Where

1 site
Noll Laboratory
University Park, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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