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Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery

Recruitingn/aAges 18 Years - anyAllUniversity of Edinburgh
NCT06800430 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur. In this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique,

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📋 Eligibility rules (as published)
INCLUSION CRITERIA: Cohort 1: Patients undergoing CABG surgery * Males and females over 18 years of age * Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy * Males and females over 18 years of age * Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts * Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy EXCLUSION CRITERIA: * Patients with a life expectancy of \< 2 years * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Patients on immunosuppressive therapies * Females of child-bearing age who are pregnant or breastfeeding, * Known allergy or contraindications to iodinated contrast or radiotracer * Patients who are unable to tolerate the supine position * Patients who are unable to provide informed consent
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What it tests

  • Hybrid [18F]-GP1, [68Ga]-DOTATATE, [68Ga]-FAPI total-body positron emission tomography and coronary computed tomography coronary angiography
  • Hybrid [18F]-GP1, [68Ga]-DOTATATE, [68Ga]-FAPI total-body positron emission tomography and coronary computed tomography coronary angiography
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Where

1 site
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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