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The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

RecruitingPhase 4Ages 18 Years - anyAllUniversity of California, San Francisco
NCT06802224 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopressors to treat low blood pressure during surgery. These medications help raise the blood pressure back up to a safe range. Two vasopressor medications are commonly used for this purpose: norepinephrine and phenylephrine. Each of these medications has slightly different effects on the heart and blood vessels (cardiovascular system). It remains unknown which of these standard medications is better for treating low blood pressure during surgery. The goal of this clinical trial is to determine which of these two medications is better at preventing injury to the kidneys after major noncardiac surge

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Surgery under general anesthesia with a surgery duration of 2 hours or more * Received intravenous vasopressors during surgery Exclusion Criteria: * Cardiac surgery * Extra-corporeal membrane oxygenation * Organ transplantation * Obstetric procedures * Procedures on the kidney * Outpatient procedures * Already receiving NE or PE or inotropes before induction of anesthesia (at the time of anesthesia start) * American Society of Anesthesiologists physical status classification 5 or 6 * Patient for whom a local protocol recommends a specific first line vasopressor * Most recent documented estimated glomerular filtration rate (eGFR) \< 15 mL/min/1.73m\^2 or preoperative renal replacement therapy within 60 days before surgery * Patients who do not have a preoperative creatinine value within 60 days before surgery * Alive patients who do not have a postoperative creatinine value
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What it tests

  • Norepinephrine
  • Phenylephrine
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Where

10 sites
University of California, San Francisco
San Francisco, United States
University of Maryland
College Park, United States
University of Michigan
Ann Arbor, United States
Henry Ford Health
Detroit, United States
Duke University Medical Center
Durham, United States
Wake Forest University School of Medicine
Winston-Salem, United States
UT Southwestern Medical Center
Dallas, United States
University of Virginia
Charlottesville, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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