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RTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography

RecruitingNAAges 13 Years - 55 YearsAllShanghai Mental Health Center
NCT06802939 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is an before-after study in the same patient, which enrolled 36 psychiatric patients with refractory auditory hallucinations. The target of patient intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period. The investigators assume that the intervention targets for each auditory hallucination patient are individualized.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinical diagnosis of schizophrenia * Must be able to right-handed * Primary school education or above * Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old) * Existence of persistent auditory hallucinations (defined as: taking sufficient antipsychotic medication for at least 6 months, combined with 3 antipsychotic medications still ineffective, and no significant improvement in auditory hallucinations symptoms, with an AHRS score still\>12) Exclusion Criteria: * MECT treatment within the past 3 months * Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury) * Taboo symptoms for rTMS treatment (such as intracranial metal implants) * Aggressive behavior and an impulse to damage equipment * Metal (including orthodontic treatment, dental implants) and tattoos inside the body * Claustrophobia
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What it tests

  • rTMS
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Where

1 site
Shanghai Mental Health Center
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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