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Effects of LH and FSH on Metabolic Regulation in Cumulus Cells

RecruitingNAAges 35 Years - 40 YearsFemaleKaohsiung Veterans General Hospital.
NCT06803199 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 35-40 years * BMI 18-30 kg/m2 * planning to undergo IVF cycles Exclusion Criteria: * Primary ovarian insufficiency * history of oophorectomy * receiving oocyte donation * Chromosome anomaly * Congenital uterine anomaly * Severe intrauterine adhesion * Malignancy * Using hormone therapy or supplements in recent 3 months
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What it tests

  • FSH and LH
  • FSH
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Where

1 site
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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