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Teicoplanin Allergy Testing Using Autologous Serum (TATAS)

RecruitingNAAges 18 Years - anyAllUniversity Hospital Southampton NHS Foundation Tr…
NCT06803758 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Allergy testing for Teicoplanin is much more unreliable than for other similar drugs. This means that we run the risk of missing serious Teicoplanin allergy, and these patients will be given another dose in future, not knowing that they are seriously allergic. Serious allergic reactions, also known as anaphylaxis, can be life threatening. The patients which we recruit to our study will come to us through the perioperative allergy service. They will have had a reaction to a general anaesthetic, but will also have had teicoplanin as part of the anaesthetic. We are not sure why allergy skin testing, which is fairly reliable for most other drugs, is so unreliable in detecting teicoplanin allergy. We do know that some drugs need to mix with proteins in the blood before they trigger an allergy. We would like to replicate this by mixing the teicoplanin with the patients' own blood and using t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients 18 years old and above who have suffered suspected anaphylaxis under anaesthesia (the 'index episode'), where teicoplanin has been given Exclusion Criteria: * Patients unable to stop drugs that would interfere with skin tests prior to study- e.g. antihistamines or certain anti-psychotics * Pregnancy * Patients under age 18 years * Patients with elevated baseline mast cell tryptase requiring further investigation * Patients with blood-borne viruses such as Hep B, C and HIV
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What it tests

  • Teicoplanin Allergy Testing using autologous serum
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Where

1 site
University Hospital Southampton
Southampton, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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