🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Carotid Plaque Characterization Using Innovative Ultrasound Techniques

RecruitingNAAges 18 Years - anyAllHospices Civils de Lyon
NCT06804707 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Strokes are the second leading cause of disability and death worldwide (according to World Health Organization in 2019). They are ischemic in origin in 80% of cases. Atheromatous disease, and more specifically carotid stenosis, is responsible for 20% of these ischemic strokes. Current recommendations, based on high levels of evidence, consider only the degree of carotid artery stenosis to define the threshold for surgical treatment. However, it is now accepted that the composition and rate of progression of atherosclerotic plaque are also criteria to be considered when selecting patients at high risk of stroke. The presence of hemorrhage and a lipid core in the atheromatous plaque, both factors of instability, is associated with a greater risk of ipsilateral ischemic events. The presence of intraplaque hemorrhage is therefore a marker of plaque instability. In this context, techniques fo

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Female or male over 18 years of age * Patients with asymptomatic or symptomatic carotid plaque (stenosis\> 50% NASCET), referred by the Hospices Civils de Lyon (HCL) vascular surgery consultation and for whom a surgical indication has been retained. * Patient having agreed to participate in the study and signed a written informed consent form * Patient affiliated to a social security scheme or equivalent. Exclusion Criteria: * Patients with contraindications to Sonovue (right-to-left shunt, severe pulmonary hypertension, allergy to the molecule) * Patients with unstable cardiovascular pathology (coronary artery disease, stroke / transient ischemic attack, cardiac rhythm disorders) * Uncontrolled hypertension * Respiratory distress syndrome * Patients with contraindications to MRI (claustrophobia, presence of metallic elements, etc.). * Gadolinium-related contraindications and precautions for use * Contraindication to dobutamine * Hypersensitivity to the active substance or to one of the constituents of Gadolinium, * Renal insufficiency with clearance \<30 ml/min/1.73 m², * Pregnant or breast-feeding patients * Patients under guardianship or trusteeship
💊

What it tests

  • blood sampling
  • ultrasound imaging exam
  • High resolution MRI plaque exam
📍

Where

1 site
Hôpital de la Croix Rousse
Lyon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy