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Polyphenol Metabotypes in People With Diabetes Type 2

Recruitingn/aAges 40 Years - 85 YearsAllUniversity Hospital, Ghent
NCT06810635 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes. Additionally, the study aims to identify factors that influence the polyphenol metabotype (transit time and gut microbial capacity to degrade polyphenols in particular).

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📋 Eligibility rules (as published)
Inclusion Criteria: * all participants * between 40-85 years * age-matched individuals without diabetes * BMI between 18.5-30 * no metabolic syndrome * persons with T2DM * at leats 2 years of clinical diagnoses of T2DM * stable medication use for at least 1 month Exclusion Criteria: * pregnancy of breastfeeding * in last month * acute use of anti/pre/probiotics * start of new drug or dietary supplements * major changes in diet * major lifestyle changes * diseases * Gastrointestinal diseases (inflammatory bowel disease) * Bariatric surgery * Other forms of diabetes (cystic fibrosis/MODY/T1DM) * Heart problems (NYHA 3/4) or previous cardiovascular events * Liver problems: non-alcohol steatohepatitis (NASH) and cirrhosis * Lung problems (COPD - GOLD 3/4), cystic fibrosis * Uncontrolled thyroid function disruption in the past 6 months * Intake of coumarin derivatives and direct oral anticoagulant medication * Anti-cancer treatment: chemo-/immunotherapy * Immonosuppressants (transplant) * Antiepileptic drugs
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What it tests

  • Oral Polyphenol Challenge Test / PPPIL
  • fasting blood sample
  • Fasting urine collection
  • 24 hours urine collection
  • Questionnaires
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Where

2 sites
Ghent University
Ghent, Belgium
Department of rehabilitation sciences - UGent
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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