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Using Antibiotics to Prevent Infections in Hemodialysis Patients During Catheter Placement

RecruitingPhase 4Ages 18 Years - anyAllWestern Galilee Hospital-Nahariya
NCT06814223 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine if prophylactic antibiotic treatment can reduce the incidence of early catheter-related infections in hemodialysis patients at high risk, including those with femoral catheter placement, atrial fibrillation, or heart failure. The main questions it aims to answer are: 1. Will prophylactic antibiotic administration reduce catheter-related infections by 50% within 45 days of catheter insertion? 2. Will this intervention decrease the rate of secondary complications such as metastatic infections, cardiovascular morbidity, and mortality? Researchers will compare patients receiving prophylactic antibiotics (e.g., cefamezine and gentamicin, or vancomycin for high-risk individuals) to those not receiving antibiotics, to assess the difference in infection rates and associated complications. Participants : * Be randomized into two groups: one rec

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hemodialysis patients scheduled for new tunneled catheter placement or replacement of an existing tunneled catheter. * Prior diagnosis of at least one of the following conditions: 1. Atrial fibrillation 2. Heart failure 3. Femoral tunneled catheter * Patients who have signed informed consent to participate in the study. Exclusion Criteria: * • Hemodialysis patients unable to provide informed consent and requiring a legal guardian. * Patients undergoing prolonged antibiotic therapy prior to tunneled catheter insertion.
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What it tests

  • • Cefamezine (2 grams) and gentamicin (80 mg) administered intravenously. • Patients with penicillin allergies, a history of methicillin-resistant Staphylococcus aureus (MRSA) infection, or known MRSA
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Where

1 site
Galilee Medical Center
Nahariya, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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