🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

AP Metabolism Transcriptomics

Recruitingn/aAges 5 Years - 17 YearsAllIRCCS Eugenio Medea
NCT06814314 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear cells. In this pilot study we intend to evaluate the transcriptomic profile of children and adolescents who are undergoing treatment with antipsychotics and show metabolic disorders, in order to compare it to the profile of similar patients who do not use antipsychotics, but show metabolic disorders, or who use antipsychotics, but do not show metabolic disorders. The hypothesis is that a different transcriptomic profile can be identified between the three populations under study, such as to allow to hypothesize that a series of transcripts can be used as early biomarkers of whether treatment with antipsychotics can induce metabolic disorders in the individual p

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * age 5-17 years; * group 1: antipsychotic users with metabolic disorders; * group 2: antipsychotic users without metabolic disorders; * group 3: non-antipsychotic users with metabolic disorders. The definition of antipsychotic use includes daily use for at least 3 months prior to enrollment. The definition of metabolic disorders includes: BMI-Z for age, sex and height \> +1 Waist circumference \> 90th percentile for age, sex and height Diastolic or systolic blood pressure \> 90th percentile for age, sex and height Fasting blood glucose \> 99 mg/dl Fasting triglycerides \> 149 mg/dl Fasting cholesterol \< 41 mg/dl. Patients with metabolic disorders are defined as those who meet at least one of the above criteria. Patients without metabolic disorders are defined as those who do not present any of the above criteria. Exclusion Criteria: * presence of diagnosed genetic conditions known to alter energy metabolism and/or nutrition; * presence of diagnosed eating disorders; * habitual use of supplements known to alter energy metabolism and/or nutrition; * concomitant use of drugs known to alter energy metabolism and/or nutrition.
💊

What it tests

  • Transcriptomic investigation
📍

Where

1 site
IRCCS Eugenio Medea
Bosisio Parini, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy