💬In plain words
What the trial is, and whether it could suit you
Type 1 diabetes (T1D) is a chronic condition, affecting 1 in 490 children under the age of 15 years. It is caused by the immune system damaging the pancreas, the organ which makes insulin. T1D has recognised stages before symptoms develop, providing an opportunity for early diagnosis, education and treatment which may delay the onset of symptoms.
Type 2 diabetes (T2D) is also a chronic condition where the body cannot make enough insulin, or cannot respond to the insulin properly. It is usually related to obesity, rather than an immune problem. It is more common in adults, but the early stages often start in childhood (up to 1 in 4 children in some clinics). Like T1D, early detection can delay onset of T2D, or even prevent it altogether.
Early diagnosis of T1D or T2D often relies on a test called the oral glucose tolerance test (OGTT), which is commonly used but not well tolerated, poss
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion criteria:
Cohort 1
* Willing and able to give informed consent for participation, or assent with parental consent
* Aged \< 18 years old
* Able to consume oral glucose drink within 10 minutes
* Undergoing an OGTT, or consent to have one
Cohort 2
* Positive for two or more islet autoantibodies at any time
* Willing and able to give informed consent for participation, or assent with parental consent
* Aged \< 18 years old
* Able to consume oral glucose drink within 10 minutes
CGM sub-study
* Willing and able to give informed consent for participation, or assent with parental consent
* Aged \< 18 years old
* Able to consume oral glucose drink within 10 minutes
* Confirmed to have stage 1, 2 or 3 T1D
* Participation in Cohort 1
Qualitative sub-study
* Willing and able to give informed consent for participation, or assent with parental consent Then EITHER
* A young person positive for two or more islet autoantibodies (15 years old and above) at any time, or parent of a young person who has experienced a metabolic test e.g. OGTT OR
* A healthcare professional involved in delivering metabolic testing
Cohort 3
* Prediabetes diagnosis as above
* Willing and able to give informed consent for participation, or assent with parental consent
* Aged \< 18 years old
* Able to consume oral glucose drink within 10 minutes
Exclusion Criteria:
Cohort 1
* Any known haemoglobinopathy
* Cystic fibrosis related diabetes
* Non-English speaker
Cohort 2
* Any known haemoglobinopathy
* Known clinical diabetes and on treatment
* Non-English speaker
* No recent weight available (within 3 months of study visit) and unable to obtain new weight measurement
CGM sub-study
* Any known haemoglobinopathy
* Cystic fibrosis related diabetes
* Non-English speaker
* Any active skin issue which would prevent the use of a CGM device
Qualitative sub-study
• Non-English speaker
Cohort 3
* Known clinical diabetes and on treatment
* Non-English speaker
* No recent weight available (within 3 months of study visit) and unable to obtain new weight measurement
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