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Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera

RecruitingPhase 3Ages 18 Years - anyAllUniversity Hospital, Brest
NCT06819644 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to validate the interest of a strategy adjusting the flow rate delivered under high-flow oxygen (HFO) therapy according to the lung volumes measured by a new technique, in intensive care patients with hypoxemic respiratory distress (HRD). The main question it aims to answer is: "The use of a technique of measurement of lung pulmonary with adjustement to the flow rate can make it possible to limite intubation in patients with HRD in intensive care?" The participants will be the patients admitted in intensive care for HRD with the need for treatment with HFO. This participants will be randomized in : * the arm control: treated by high flow oxygen therapy according to standard procedures. * or in the experimental arm : treated by high flow oxygen therapy with adjustement of ventilatory parametres based on lung volume measurements, obtained by the depth

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with hypoxemic respiratory distress define by the following 4 criteria: * Respiratory rate ≥ 25 breaths per minutes * A ratio of the partial pressure of arterial oxygen (PaO2) to the FiO2 ≤ 300 mmHg while the patient is breathing oxygen at a flow rate of 10 liters per minutes or more * A partial pressure of arterial carbon dioxide (PaCO2) not higher than 45 mmHg * An absence of clinical history of underlying chronic respiratory failure Exclusion Criteria: * A do-not-intubate order * Pregnant or lactating woman * Cardiogenic pulmonary edema * Exacerbation of asthma * Hemodynamic instability with use of vasopressor at significant dose (norepinephrine \> 0.5 mg/h) * A Glasgow Coma Scale of 12 points of less * Contraindications to non-invasive ventilation * Urgent need for endotracheal intubation * High flow oxygen therapy started within 48 hours before inclusion * Patient under legal protection or deprived of liberty
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What it tests

  • high flow oxygen therapy rate adjusted of lung volumes measured
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Where

8 sites
Brest, University Hospital
Brest, France
AP-HP - Hôpital Louis Mourier
Colombes, France
AP-HP - Hôpital Henri Mondor
Créteil, France
CH Morlaix
Morlaix, France
CHR Orléans
Orléans, France
CH Poitiers
Poitiers, France
CHU Rennes
Rennes, France
CHU Tours
Tours, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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