Accuracy of Static Guided Implant Surgery: 3D-printed vs Milled Surgical Guides

Inclusion Criteria: * Male or female patients with one to four missing teeth, where dental implants are planned and where a tooth-supported or tooth-mucosal supported surgical guides can be fabricated. Free-ended situations will be allowed. * Edentulous sites with at least 3 months of healing after tooth extraction. * Staged hard and soft tissue augmentation will be permitted. In cases of previous bone augmentation (e.g. staged horizontal bone regeneration or lateral sinus lift), a minimum healing period of 6 months should be respected. In cases of previous soft tissue augmentation procedures, a minimum healing period of 2 months should be respected. Simultaneous close sinus lift procedures will be allowed when there is a minimum posterior bone height of 6 mm. * Implants should be surrounded by at least 1.5 mm of bone. * Periodontally healthy patients or with stable periodontal conditions after periodontal therapy. Periodontitis will be defined according to the EFP-AAP 2017 World Workshop Classification (Papapanou PN, Sanz M, et al., 2018): interdental CAL is detectable at ≥2 non-adjacent teeth or buccal or oral CAL ≥3 mm with pocketing ≥3 mm is detectable at ≥2 teeth, but the observed CAL cannot be ascribed to non-periodontitis-related causes such as 1) gingival recession of traumatic origin; 2) dental caries extending in the cervical area of the tooth; 3) the presence of CAL on the distal aspect of a second molar and associated with malposition or extraction of a third molar, 4) an endodontic lesion draining through the marginal periodontium; and 5) the occurrence of a vertical root fracture. * Aged 21 years and over and able to sign an informed consent form. * Enough available bone assessed on CBCT to place Klockner Vega implants of diameters ranging from 3.5 to 4.5 mm and lengths between 8 and 12 mm. Exclusion Criteria: 1. Systemic * Completely edentulous patients or patients requiring mucosal- or bone-supported surgical guides. * Compromised general health (ASA IV-VI patients). * Systemic diseases which could influence the outcome of therapy (uncontrolled diabetes mellitus, bone disorders, etc.). * Pregnant or nursing women. * Chronic use of corticosteroids, nonsteroidal anti-inflammatory drugs (NSAID), or immune-modulator drugs (any type and dose). * Patients who need medications that affect bone metabolism (bisphosphonates, any type and dose). * Chronic diseases of the oral mucosa. * Smokers of \>10 cigarettes/day. * \>25% plaque index at the time of re-evaluation after non-surgical periodontal therapy and OHI * Unable to attend all study visits. * Need of simultaneous bone augmentation after implant placement to treat dehiscence and fenestration type defects or to augment bone contour (\<1.5 mm of bone all around the implant circumference). 2. During surgery * Lack of primary stability assessed by hand testing after implant placement. * Less of 2 mm of keratinized mucosa, both at the lingual and buccal sites. * Lack of guide adjustment verified through the fitting windows.