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Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis

Recruitingn/aAges 18 Years - 45 YearsFemaleNantes University Hospital
NCT06820450 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged 18 to 45 * Free, informed and written consent from the patient to participate in the study * Good understanding of the French language * Patient affiliated to or benefiting from a social security or similar scheme Specific inclusion criteria for each group: Group 1. Controls. * Women with no laparoscopically confirmed signs suggestive of deep endometriosis. * No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis. Group 2. Cases of deep endometriosis. * Newly diagnosed women (less than 12 months). * Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings). Exclusion Criteria: * Intercurrent diagnosis of pregnancy. * Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS). * Acute infection.
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What it tests

  • Blood test
  • urine sample
  • vaginal sample
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Where

1 site
CHU de Nantes
Nantes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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