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Short-term Effects of Osteopathic Manipulations on Heart Rate Variability in Lung Cancer Patients - A Randomized Pilot Study

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Henri Duffaut - Avignon
NCT06822348 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In France, the number of new cancer cases each year is rising steadily, while the number of deaths, although falling, is still around 157,000, including 23,000 from lung cancer alone. According to the French National Cancer Institute, there are three main methods of treating cancer: chemotherapy, radiotherapy and surgery. In recent years, new therapies have been developed, notably with the advent of immunotherapy and targeted therapies. On the other hand, although non-medical interventions (NMIs) such as osteopathy are recognized as improving the quality of life of cancer patients, there has been little research into their contribution when combined with conventional therapies. Studies have shown a link between the vagus nerve and cancer. Through its actions, the vagus nerve regulates homeostasis and immunity at local and regional levels, reducing systemic inflammation but maintaining l

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient with stage 4 lung cancer. * WHO stage ≤ to 2. * Dyspnea grade ≤ 2 on the mMRC scale (modified Medical Research Council) * Patient undergoing chemotherapy for the first time * Patient with less than 5% artifact rate during rMSSD measurement. * Patient with SDNN less than 70 ms. * Voluntary patient who has signed the informed consent form. * No contraindications to osteopathic manipulation. Exclusion Criteria: * Patient with unilateral or bilateral vagotomy. * Patient with cardiac arrhythmia. * Patient undergoing treatment influencing cardiac rhythm (anti-arrhythmic drugs, beta-blockers, etc.) * Patient with relapsed cancer already treated with chemotherapy.
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What it tests

  • Osteopathic treatment
  • Quality of life assessment
  • Anxiety assessment
  • Heart rate variability assessment
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Where

1 site
Centre Hospitalier d'Avignon, Hôpital Henri Duffaut
Avignon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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