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Cryoprobe Biopsy and Chronic Rejection in Lung Transplant Recipients

RecruitingNAAges 18 Years - 99 YearsAllMayo Clinic
NCT06824402 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate which biopsy collection method helps to better diagnose rejection and relevant pathologic findings in lung transplant recipients. The main questions it aims to answer are: Does the 1.1 mm cryoprobe or the biopsy forceps provide better quality samples of lung tissue for detecting rejection in transplant recipients? How much tissue is adequate for lung transplant 1.1 mm cryobiopsy samples as compared to biopsy forceps? Which samples received by the pathologist did they find they were most confident to exclude rejection, based on their satisfaction with the samples? Which collection method has the least amount of procedural time? Researchers will compare lung tissue samples obtained using a 1.1mm cryoprobe and a biopsy forceps during the lung transplant. Participants will: Be randomly assigned to receive either the cryoprobe or biopsy fo

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Male and female lung transplant recipients age \>18 at the time of informed consent * Patients clinically meet indication for post-transplant lung biopsy or planned routine surveillance and have been scheduled for bronchoscopy with transbronchial biopsy. * Be willing and able to sign the informed consent. Exclusion Criteria * Patients with known bleeding diathesis * Platelet count \<50,000 per ฮผL within 14 days of the biopsy procedure * Current use of systemic anticoagulation or antiplatelet therapy without the ability to hold therapy for the recommended amount of time prior to an invasive procedure (aspirin monotherapy is acceptable) * Inability or unwillingness to give informed consent or study procedures * Pregnant or nursing females, or females who intend to become pregnant * Females of child-bearing potential who decline a pregnancy test prior to enrollment * If an investigator does not feel that this study is in the subject's best interest or would be a good fit for the study. * International Normalized Ratio (INR) \>1.5 * Do Not Resuscitate (DNR) status * Do Not Intubate (DNI) status * Single lung transplant recipients
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What it tests

  • Forceps Biopsy
  • Cryoprobe Biopsy
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Where

1 site
Mayo Clinic in Rochester
Rochester, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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