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Orthodontic Treatment on Oral Microbiota and Salivary Proteins

Recruitingn/aAges 6 Years - 18 YearsAllXi'an Jiaotong University
NCT06824493 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

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📋 Eligibility rules (as published)
Inclusion Criteria: * No carries and White spot * No missing teeth * No history of oral treatment * No malocclusion * No systemic diseases Exclusion Criteria: * Antibiotic use in the past three months * A history of long-term medication use * A history of dental fillings * Unable to attend regular follow-ups
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What it tests

  • no interventions
  • None-placebo
  • No Intervention: Observational Cohort
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Where

1 site
tomatology Hospital of Xi'an Jiaotong University,
Xi'an, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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