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Bronchodilators and Lung Mechanics During Exercise in COPD

RecruitingPhase 4Ages 40 Years - anyAllDr. J. Alberto Neder
NCT06825013 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD. The goal of this clinical trial is to determine whether bronchodilators lower resistance in the smallest airways in the lungs, and whether this will improve the feeling of breathlessness in these patients. The main questions the investigators attempt to answer are: * In patients with COPD, does treatment with a short-acting bronchodilator improve small airway resistance during exercise? * In patients with COPD, does acute treatment with short-acting bronchodilator improve breathlessness and exercise endurance? The investigators will compare short-acting bronchodilators to placebo (a substance that contains no drug) to see if the bronchodilator medications improve small airway resistance and b

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of COPD * Male or female ≥40-years-of-age * Current or former smokers with ≥20 pack-year history * Forced expiratory volume in 1 second (FEV1)/ forced vital capacity (FVC)\<lower limit of normal * Pre-Post Change of FVC ≥ 10% predicted after 400 mcg inhaled salbutamol * Functional residual capacity ≥120%predicted and/or the upper limit of normal * Modified Medical Research Council dyspnea scale ≥ 2 * Clinically stable as defined by no exacerbations in the preceding 6 weeks * Ability to provide informed consent and perform all study procedures Exclusion Criteria: * Major cardiopulmonary diseases other than COPD (asthma, interstitial lung disease, pulmonary hypertension, and congestive heart failure) * Neuromuscular or musculoskeletal disease * Use of daytime oxygen or exercise induced O2 desaturation to \< 80% on room air; * Any other disorder that may contribute to exertional dyspnoea and/or exercise intolerance * Any contraindication to cardiopulmonary exercise testing
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What it tests

  • Bronchodilators inhalation
  • Placebo
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Where

1 site
Respiratory Investigation Unit, Kingston Health Sciences Center
Kingston, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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