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Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Study

RecruitingNAAges 65 Years - 85 YearsAllUniversita di Verona
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In plain words

What the trial is, and whether it could suit you

This study is designed to evaluate the safety, feasibility, and effectiveness of a 12-week eccentric exercise program for older adults with sarcopenia (muscle loss) or sarcopenic obesity and chronic heart failure (HF). The program aims to improve physical performance, muscle strength, and overall health without causing excessive strain on participants. Eccentric exercise has shown potential benefits for improving muscle function, and this study will help determine if it is a safe and effective option for individuals with heart failure and muscle loss. Study Goals: The primary aim of this study is to test the feasibility and effectiveness of an eccentric exercise program for older adults with sarcopenia and CHF. The study will monitor physical performance, adherence to the program, and participants' ability to tolerate the exercise, as well as any impact on heart and muscle health. Stud

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Participants must meet all of the following criteria: * Age 65 to 85 years * Diagnosed with stable heart failure (HF), defined as: * Preserved left ventricular ejection fraction (≥50%) or * Reduced ejection fraction (≤40%) * Classified as New York Heart Association (NYHA) class 1, 2, or 3 * Meet the diagnostic criteria for sarcopenia or sarcopenic obesity: * Sarcopenia: Impaired muscle strength with the Five-repetition chair stand test time \>15 seconds (normal weight) or \>17 seconds (patients with obesity) * Reduced muscle mass according to the European Working Group on Sarcopenia (EWGSOP) or Sarcopenic Obesity: Based on the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO). * For EWGSOP: Sarcopenia as Class I: Skeletal muscle mass index (kg/m²) * Males: ≤10.75 kg/m² * Females: ≤6.75 kg/m² * For EWGSOP: Sarcopenia as Class II: Skeletal muscle mass index (kg/m²) * Males: ≤8.50 kg/m² * Females: ≤5.75 kg/m² * For ESPEN-EASO: Obesity: waist circumference calculated in centimeters (cm) * Males: ≥102 cm * Females: ≥ 88 cm Sarcopenia as Class I: Skeletal muscle index as a percentage of body weight (%) * Males: 31.3-37% * Females: 22.1-27.6% Sarcopenia as Class II: * Males: \<31.5% * Females: \<22.1% Exclusion Criteria: Participants will be excluded if they meet any of the following conditions: * Severe obstructive heart disease * Aortic valve stenosis * Severe arrhythmias identified during initial stress testing * Intracavitary thrombosis * Severe pulmonary hypertension (\>70 mmHg) * History of venous thromboembolism within the previous three months * History of heart transplantation * Medical conditions that significantly limit functional capacity beyond the impact of HF
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What it tests

  • Aerobic eccentric intervention
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Where

2 sites
University of Verona
Verona, Italy
University of Verona
Verona, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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