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Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation

RecruitingPhase 1, Phase 2Ages 18 Years - 60 YearsAllJordan University Hospital
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In plain words

What the trial is, and whether it could suit you

For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts from healthy human donors present a scalable solution. This study aims to evaluate the biocompatibility and effectiveness of two types of allogenic dentin grafts-demineralized dentin allografts (DDA) and whole tooth allografts (WTA)-for alveolar ridge preservation, contributing to innovative, sustainable dental practices.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion and Exclusion Criteria for Donors: Inclusion Criteria: * Students, interns, or residents willing to participate and provide informed consent. * No history of systemic diseases such as diabetes, hepatitis, or immune disorders. * Negative blood screening for HIV, HBV, and HCV. * Non-smokers or individuals who have not smoked within the last six months. Exclusion Criteria: * History of systemic conditions affecting oral or overall health. * Positive blood tests for communicable diseases. * Active oral infections or untreated dental caries. * Pregnant or lactating individuals. * Individuals with a history of smoking or substance abuse within the last six months. Inclusion and Exclusion Criteria for Recipients: Inclusion Criteria: * Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons. * Patients in good systemic health without conditions that impair bone healing. * Willingness to provide informed consent and participate in follow-ups. Exclusion Criteria: * Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration. * Active oral infections at extraction sites. * History of radiation therapy to the head and neck region. * Smoking or smoking history within the last six months. * Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids). * Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria: * Severe periodontal disease. * Irreversible pulpitis or structural damage. * Non-restorable condition impacting oral health or functionality.
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What it tests

  • DDA
  • WTA
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Where

1 site
Jordan University Hospital
Amman, Jordan
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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