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High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)

RecruitingNAAges 18 Years - 70 YearsAllFundación Pública Andaluza para la Investigación …
NCT06833944 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects. The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown

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📋 Eligibility rules (as published)
Inclusion criteria: * Individuals with a diagnosis of genetic FH. * \> 18 years old. * Minimum follow-up of 1 year in the Vascular Risk Clinic of the Virgen de las Nieves University Hospital (HUVN). * Clinical and treatment stability. * Non-pathological angio-TAC of coronary arteries in the 2 years prior to the study (for participants \>45 years old). Exclusion criteria: * Inability to read, understand and sign the informed consent. * Contraindications to exercise. * History of clinical CVD (ischemic heart disease, stroke, and/or peripheral arterial disease).
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What it tests

  • HIIT intervention program
  • MICT intervention program
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Where

1 site
Virgen de las Nieves University Hospital
Granada, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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