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Comparative Assessment of Esophagitis in Cases With and Without Esophageal Motility Disorders: A Prospective Study

RecruitingNAAges 18 Years - 75 YearsAllAsian Institute of Gastroenterology, India
NCT06835374 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Achalasia is a neuro-degenerative disorder marked by changes in the peristalsis of the esophagus and the lack of relaxation in the lower esophageal sphincter (LES), thought to be due to damage to the myenteric plexus with an unknown cause.1 Per-oral endoscopic myotomy (POEM) is an established endoscopic treatment modality for achalasia. Leading gastrointestinal (GI) societies endorse POEM as one of the primary treatment option for achalasia.This study aims to characterize and compare the morphological characteristics of reflux related erosions after the POEM procedures versus those in cases without esophageal motility disorders. Data collection 1. Demographic characteristics: Age, gender, type of achalasia 2. Manometry findings (pre and post POEM): integrated relaxation pressure, lower esophageal sphincter pressure 3. Comorbidities 4. Medications 5. Eckardt score: before procedure and

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age≥18y, 2. confirmed diagnosis of Achalasia, 3. No contraindication to POEM, 4. erosive esophagitis on endoscopy Exclusion Criteria: 1. Non-esophageal esophageal motility disorders, 2. Treatment other than POEM, 3. current PPI use before assessment for GERD
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What it tests

  • Per oral endoscopy myotomy (Per oral endoscopy myotomy)
  • Endoscopy procedure
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Where

1 site
Asian Institute of Gastroenterology Hospital
Hyderabad, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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