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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

RecruitingNAAges 18 Years - anyAllMuehlenkreiskliniken, MKK
NCT06836830 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults \>= 18 years * non-traumatic OHCA * mechanical ventilation via airway device Exclusion Criteria: * Patients \< 18 years, * traumatic cause of OHCA, * no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)
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What it tests

  • PEEP 5 mbar
  • ZEEP 0 mbar
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Where

3 sites
Emergency Medical Services
Gütersloh, Germany
JWK Minden
Minden, Germany
Emergency Medical Services
Osnabrück, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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