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COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial

RecruitingNAAges 18 Years - 40 YearsFemaleDow University of Health Sciences
NCT06836986 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are: Does norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension. Participants will: Be administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. American society of anesthesiologists II and III patients 2. Age 18-40years 3. Gestational age 32 weeks and above Exclusion Criteria: 1. Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg. 2. Baseline mean arterial pressure less than 70 mmHg. 3. Antepartum hemorrhage/intraoperative blood loss greater than 1000ml 4. history indicative of cardiovascular or neurological disease. 5. known fetal abnormality. 6. Patients taking serotonin reuptake inhibitor, Tricyclic antidepressants,monoamine oxidase inhibitors. 7. Maternal situations requiring immediate administration of general anesthesia
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What it tests

  • Norepinephrine Bolus
  • Phenylephrine bolus
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Where

1 site
Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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