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Washed Microbiota Transplantation Combined With Enteral Nutrition for Gastroptosis

Recruitingn/aAges 18 Years - 100 YearsAllThe Second Hospital of Nanjing Medical University
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In plain words

What the trial is, and whether it could suit you

This is a observational study to explore the efficacy and safety of washed microbiota transplantation (WMT) combined with nutritional support for gastroptosis patients

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Subjects must meet all of the following inclusion criteria to enter the study: 1. Clinically diagnosed with gastroptosis; 2. Meets the diagnostic criteria for malnutrition (fulfilling any one of the following two criteria): * Weight loss (weight loss \>5% within the last 6 months or \>10% over more than 6 months); * Low BMI (BMI \<18.5 kg/mยฒ for individuals \<70 years old; BMI \<20 kg/mยฒ for individuals โ‰ฅ70 years old); 3. Males aged โ‰ฅ18 years and non-pregnant, non-lactating females aged โ‰ฅ18 years; 4. Willing to voluntarily sign a written informed consent form and agrees to follow medical advice for regular follow-up examinations and monitoring after the completion of treatment. Exclusion Criteria: * Subjects meeting any of the following exclusion criteria must be excluded from the study: 1. Patients with severe depression, anxiety, or cognitive impairment that affects normal physician-patient communication and treatment planning; 2. Patients with poor compliance who cannot accept treatment regimens such as nasogastric enteral nutrition; 3. Anticipated survival time \<3 months; 4. Clinically significant cardiovascular diseases, including heart failure (NYHA Class III-IV), uncontrolled coronary artery disease, cardiomyopathy, arrhythmia, history of myocardial infarction, hemodynamic instability at enrollment, unstable vital signs, or anticipated risk events during treatment; 5. Poor pulmonary function deemed by investigators to impact study treatment (e.g., acute exacerbation of COPD or requirement for long-term oral/intravenous corticosteroids \[excluding inhaled corticosteroids\]); 6. Active severe clinical infections (\> Grade 2 per NCI-CTCAE v5.0), including patients with intestinal fungal, viral, or tuberculosis infections; 7. Inability to cooperate with intestinal tube placement or contraindications to intestinal tube placement; 8. Use of medications affecting or modulating gut microbiota within the past 48 hours; 9. Lack of legal capacity or restricted legal capacity; 10. Hematologic disorders unsuitable for blood draw examinations; 11. Other severe medical conditions deemed by investigators to preclude patient enrollment.
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What it tests

  • Not listed
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Where

1 site
Department of Microbiota Medicine & Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University
Nanjing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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