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Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes

RecruitingPhase 4Ages 18 Years - anyAllMichelle Zeller
NCT06840756 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion. Hence, transfused patients can currently receive sex-matched and/or unmatched RBCs when transfusions are given. Sex-matched stem cell transplants, and some solid organ transplants, have shown that sex-matching donor to recipient improves patient outcomes. Recent exploratory studies have also suggested that patient outcomes could be improved by sex-matching for RBC transfusion. There is emerging evidence of underlying biologic mechanism(s) to support these observations. This study is designed as a randomized controlled trial and will explore the impact on patients who receive RBC transfusions from donors of the same sex ("sex-matched") compared with donors of the opposite sex ("sex-mismatched"). The trial will

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (age ≥18); * Admission to a participating ICU; * Requiring RBC transfusion. Exclusion Criteria: * Requirement for a specialized RBC product or unit not readily available in inventory (e.g., rare blood type, washed RBCs, complex RBC antibodies, etc.); * Massively bleeding patient (i.e., ≥4 units of blood ordered at one time, or Massive Hemorrhage Protocol initiated, or an urgent blood request made); * Sex unknown or sex other than male or female (i.e. intersex); * Do not have a valid Ontario Health Insurance Plan (OHIP) health card number.
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What it tests

  • Sex-mismatched red blood cell transfusions
  • Sex-matched red blood cell transfusions
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Where

8 sites
Hamilton General Hospital
Hamilton, Canada
Kingston Health Sciences Centre
Kingston, Canada
London Health Sciences Centre
London, Canada
Lakeridge Health Oshawa
Oshawa, Canada
The Ottawa Hospital
Ottawa, Canada
Sunnybrook Health Sciences Centre
Toronto, Canada
Mount Sinai Hospital
Toronto, Canada
Toronto General Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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