Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis

Inclusion Criteria: * All patients ≥ 8 years with a preoperative diagnosis of acute appendicitis either with or without clinical or radiological suspicion of CA undergoing a laparoscopic appendectomy for intra-operative confirmed CA that can provide a signed written consent form. Exclusion Criteria: * Age under 8 years; * Not able to give informed consent (language barrier, legally incapable) * Any contraindication for the use of the study medication: * Hypersensitivity to clindamycin or to any of the excipients benzyl alcohol, sodium edetate, water, or to lincomycin; * Hypersensitivity to gentamicin or to sodium metabisulfite: particularly in asthmatic patients, this may trigger bronchospasms and anaphylactic shock or to any of the excipients: disodium edetate, sodium hydroxide, sodium metabisulfite (E223), water for injections; * Severe sepsis defined as sepsis-induced tissue hypoperfusion or organ dysfunction that includes any of the following thought to be caused by the infection: * Sepsis-induced hypotension * Lactate above upper limits laboratory normal * Urine output \<0.5 mL/kg/h for more than 2h despite adequate fluid resuscitation * Acute lung injury with PaO2/FiO2 \<250 in the absence of pneumonia as infection source * Acute lung injury with PaO2/FiO2 \<200 in the presence of pneumonia as infection source * Creatinine \>2.0 mg/dL (176.8 μmol/L) * Bilirubin \>2mg/dL (34.2 μmol/L) * Platelet count \< 100,000 μL * Coagulopathy (international normalized ratio (INR) \> 1.5); * ASA IV score; * Known malignancy; * Renal dysfunction (i.e. eGFR ≤ 60); * Immunocompromised patients (i.e. hematological malignancies, HIV/AIDS, bone marrow transplantation, splenectomy, genetic disorders such as severe combined immunodeficiency, chemotherapy, dialysis, solid organ transplant, and immunosuppressant use (such as corticosteroids in patients with rheumatoid arthritis)); * Pregnancy; * Known allergies to either gentamicin or clindamycin; * Known colonization of bacteria resistant to either gentamicin or clindamycin;