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The Impact of Ultrasound-Guided Superficial and Deep Paravertebral Nerve Blocks at the Superior Costotransverse Ligament on Hemodynamics During the Induction Phase of Thoracoscopic Lung Lobectomy: A Multicenter, Double-Blind, Randomized Controlled Trial

RecruitingNAAges 18 Years - anyAllNanjing First Hospital, Nanjing Medical University
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In plain words

What the trial is, and whether it could suit you

This study aims to determine whether performing a paravertebral nerve block at the superficial surface of the superior costotransverse ligament (SCTL) (without needle penetration of the SCTL) is more effective in maintaining hemodynamic stability during the induction phase of thoracoscopic lung lobectomy compared to the deep surface of the SCTL (with needle penetration of the SCTL). This is a multicenter, double-blind, randomized controlled trial enrolling a total of 168 participants across five hospitals. To investigate the effects of different nerve block methods on hemodynamics during induction, participants will be allocated to either the deep plane SCTL block group (T group) or the superficial plane SCTL block group (S group) using a stratified randomization scheme. The stratification accounts for a 40% proportion of hypertensive patients within each treatment group at each center.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients scheduled for elective two-port video-assisted thoracoscopic lobectomy * Age: โ‰ฅ18 years * ASA classification: I-III * BMI: 18-30 kg/mยฒ Exclusion Criteria: * Severe hypertension (SBP โ‰ฅ180 mmHg or DBP โ‰ฅ110 mmHg) * MAP \<70 mmHg before anesthesia induction * Emergency surgery * Severe cardiovascular disease, including history of cerebral or thoracic/abdominal aortic aneurysm * Congestive heart failure (New York Heart Association class III or IV) * Untreated or unstable ischemic heart disease * Severe aortic or mitral valve disease * Pregnancy or lactation * Coagulation disorders * Bacteremia, sepsis, or infection at the puncture site * Allergy to study-related drugs * Severe liver and kidney dysfunction * Neurological disorders, spinal disease (deformity or trauma), history of spinal surgery, or abnormal skin sensation in the thoracic or back region * Existing or anticipated difficult airway management * Other conditions deemed unsuitable for inclusion by the investigators Forty patients who required CT (3D) imaging technology to observe drug diffusion after the implementation of the two methods were included as follows: patients who were scheduled to undergo double-hole thoracoscopic lobectomy, aged โ‰ฅ18 years, ASA grade I to III, BMI 18 to 30kg/m2, and required preoperative CT localization. Exclusion criteria In addition to the above conditions, patients with a history of anaphylaxis induced by contrast agents should be excluded.
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What it tests

  • SCTL superficial plane block
  • SCTL deep plane block group
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Where

1 site
Nanjing First Hospital
Nanjing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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