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Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

RecruitingPhase 2Ages 40 Years - 85 YearsAllUniversity of Pennsylvania
NCT06842745 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

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📋 Eligibility rules (as published)
Inclusion Criteria: * Left Hemisphere stroke * Stroke occurred more than 6 months ago * Mild Aphasia (WAB AQ score \> 85) * Proficient in English Exclusion Criteria: * Ongoing substance or alcohol abuse * Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis) * Active psychiatric disorders (i.e. bipolar disorder, schizophrenia) * Pacemaker or cardiac defibrillator * Diagnosis of tinnitus * Epilepsy, or seizure in the past 6 months
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What it tests

  • Transcranial Magnetic Stimulation (TMS)
  • Speech-Language Therapy (SLT)
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Where

1 site
University of Pennsylvania
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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