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Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave

RecruitingNAAges 60 Years - 85 YearsAllUniversity of Ottawa
NCT06842953 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself. At high levels of humidity, the efficiency of sweating decreases causing a greater rise core temperature and burden on the cardiovascular system. In this context, increasing temperatures and humidity with climate change thus pose a potential compound risk for human health. While humidity's role in heat-health outcomes could substantially alter projections of health burdens from climate change, the impact of humidity on physiological strain in vulnerable people in relation to the indoor environment has yet to be evaluated. In a recent study delineating the physiological effects of the proposed 26°C indoor upper limit (PMID: 38329752), relative humidity was set to 45% in all cond

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📋 Eligibility rules (as published)
Inclusion Criteria: * Non-smoking. * English or French speaking. * Ability to provide informed consent. * with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis Exclusion Criteria: * Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness). * Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy). * Uncontrolled hypertension - BP \>150 mmHg systolic or \>95 mmHg diastolic in a sitting position. * Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.). * Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable. * Cardiac abnormalities identified during screening
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What it tests

  • Simulated indoor overheating
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Where

1 site
University of Ottawa
Ottawa, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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