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A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer.

RecruitingPhase 2, Phase 3Ages 18 Years - anyAllZhejiang Raygene Pharmaceuticals Co., Ltd
NCT06844357 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This phase I/II clinical trial aims to determine the efficacy and safety of TATE compared to TACE in patients with intermediate-stage HCC. The results will provide valuable insights into the potential benefits of TATE as a novel treatment option for HCC.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients diagnosed with primary hepatocellular carcinoma according to AASLD criteria. * No evidence of extrahepatic metastasis, regional lymph node involvement, or vascular tumor thrombus. * Patients must be eligible for TAE or TACE treatment. * ECOG ≤ 1. * Child-Pugh score ≤ 7. * Adequate bone marrow, liver, and kidney function is required. Exclusion Criteria: * History of liver transplantation. * Previous radioemblization or radiotherapy for liver tumors. * severe cardiovascular or renal diseases, active systemic infections. * Clinically significant hypoxia (oxygen saturation \< 92% without oxygen supplementation)
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What it tests

  • tirapazamine
  • Transarterial Embolization (TAE)
  • TACE
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Where

2 sites
Zhongda Hospital, Affiliated to Southeast University
Nanjing, China
Lishui Central Hospital
Lishui, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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