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Evaluation of AI Models in Determining the Optimal PEEP

Recruitingn/aAges 18 Years - anyAllKanuni Sultan Suleyman Training and Research Hosp…
NCT06844916 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

his study is designed as a prospective observational clinical trial. Patients over 18 years old who are hemodynamically stable and require mechanical ventilation in the Intensive Care Unit (ICU) will be included. The inclusion criteria ensure that participants require individualized ventilatory optimization. The study will involve a comparison between Artificial Intelligence (AI)-generated Positive End-Expiratory Pressure (PEEP) recommendations and expert-determined PEEP levels. ICU specialists will perform PEEP titration manually based on standardized protocols, identifying the lower inflection point (LIP) and upper inflection point (UIP) to optimize ventilation. The pressure-volume (P-V) curve will be analyzed to ensure optimal alveolar recruitment and prevent overdistension. Study Procedures Participants will: Undergo systematic mechanical ventilation assessments, including inspir

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 years or older (adult patient group). * Patients requiring mechanical ventilation in the intensive care unit (ICU). * Hemodynamically stable patients with stable blood pressure and heart rate. * Patients with complete medical records, including arterial blood gas values and ventilation parameters. * Patients whose legal representatives (if applicable) have provided informed consent for study participation. Exclusion Criteria: * Patients receiving extracorporeal membrane oxygenation (ECMO). * Patients with severe hemodynamic instability, such as refractory hypotension or arrhythmias requiring continuous vasopressor support. * Patients with incomplete medical records, particularly those missing critical data on ventilation parameters or arterial blood gas analysis. * Patients or their legal representatives who decline participation in the study.
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What it tests

  • AI-Assisted PEEP Optimization
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Where

1 site
Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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