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Promoting Optimal Treatment Choices in Neonates With Suspected Early-Onset Sepsis

Recruitingn/aAges any - 3 DaysAllFranciscus Gasthuis
NCT06845332 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral switch therapy. These strategies have been proven to be effective and safe and are already applied in several Dutch hospitals. However, this is not the case for all hospitals, leading to significant variations in clinical practice. To facilitate the translation of evidence into practice, active implementation will take place. The primary research design is a prospective implementation study, using a multicenter, non-randomized pre-post design. The aim is to assess the impact of implementing a bundle of antibiotic stewardship interventions (including the EOS calculator, PCT-guided therapy and iv-to-oral switch therapy) in Dutch hospitals, using a multicomponent imple

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📋 Eligibility rules (as published)
Inclusion Criteria: * Neonates born at 34 weeks of gestation or later * 0-3 days old Exclusion Criteria: * stillborn neonates
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What it tests

  • Not listed
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Where

11 sites
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands
Gelre Ziekenhuis
Apeldoorn, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
Treant Ziekenhuis
Emmen, Netherlands
Admiraal de Ruyter Ziekenhuis
Goes, Netherlands
Tjongerschans Ziekenhuis
Heerenveen, Netherlands
Zuyderland Medisch
Heerlen, Netherlands

…and 3 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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