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โ† Trials
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Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients

RecruitingNAAges 18 Years - anyAllAssistance Publique Hopitaux De Marseille
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In plain words

What the trial is, and whether it could suit you

The pathophysiological process common to neuropathies is fatty replacement of muscle tissue, more commonly known as intramuscular fat fraction (F.F). MRI is an imaging technique that enables us to distinguish between muscle and fat tissue, and thus to objectify in vivo structural changes within nerves and muscles in neuropathic patients. In addition to visualizing these changes, quantitative neuromuscular MRI (qMRI) can be used to quantify a number of biomarkers associated with these pathophysiological processes. Over the past few years, this procedure has become a relevant tool in a number of neuromuscular pathologies, such as acquired and hereditary neuropathies. Thanks to its non-ionizing nature and its ability to explore tissues in three dimensions, MRI is the technique of choice for evaluating these diseases, complementing the clinical and electrophysiological scores available. In

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Male or female between 18 and 80 years of age, * Patients who have freely given their consent to participate in this study, * Patient with genetically confirmed hereditary CMT neuropathy * or patient with an acquired demyelinating neuropathy such as typical PIDC or anti-MAG of typical form * or a patient with a genetically confirmed pathogenic mutation in the transthyretin (TTRn) gene, * Patients who are beneficiaries or entitled beneficiaries of a social security scheme. Exclusion Criteria: * Patients with co-morbidity or a history of other peripheral neuropathy, * Patients with alcohol or psychoactive substance abuse, * Patients with contraindications to MRI exploration: claustrophobia, pacemakers, Holter systems, IUDs, metal surgical clips, metal prostheses or implants (or other metal foreign bodies), * Patient unable to perform the MRI due to severe handicap, * Patient in a period of exclusion from another research protocol at the time of signing the consent/non-opposition form, * Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women), * Persons who cannot read and understand the French language well enough to be able to give their consent to participate in research.
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What it tests

  • Quantitative neuromuscular MRI
  • Neuromuscular ultrasound
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Where

1 site
Assistance - Publique Hรดpitaux de Marseille
Marseille, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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